endocytotic role of ndk phosphins and dynamin
| PAG Title | endocytotic role of ndk phosphins and dynamin |
| PAG ID | WAG001028 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Reliable neurotransmitter release requires the presence of sufficent numbers of syptic vesicles. The process of syptic vesicle endocytosis (SVE) is coordited by a group of proteins called dephosphins. The current set of seven known dephosphins are nerve tremil proteins with little or no structural hoimology but satisfy two essential criteria: they are essential for SVE and they are rapidly and coorditely dephosphorlyated in response to a calcium influx through voltage-dependent calicium channels. The calicium sigl is mediated by calmodulin (CaM) and calcineurin. Each dephosphin plays an essential role in overlapping phases or segments of the cycle. The four phases of SVE are nucleation, invagition, fission and uncoating. In this diagram the interlization of the vesicle is the uncoating step. In order to illustrate the complexity of this process the initial display of the protein is labelled with a me and a number. This number is then used at the decloaking or uncoating step to show the release and seperation of the various factors. Each step in the process has a different set of complex components. The components are shown in highlighted boxes above. The nucleation phase initiates with the activation of CaM/Calcineurin and the subsequent dephosphorylation of AP180. AP180 and clathrin are then recruited to the membrane by AP2 and PtdIns(4,5)P2 (comma shaped molecule in the diagram). Nucleation is completed by the addition of epsin and eps15. Invagition proceeds with the formation of the amphiphysin1/2 heterodimer and its addition to the maturing vesicle surface complexes. The fil components, dymin and syptojanin, are recruited to the budding vesicle by the amphiphysin1/2 heterodimer. Dymin forms a complete ring around the vesicle neck and completes fission via its PtdIns(4,5)P2 stimulated GTPase activity. After interlization the vesicle is quickly uncoated, in a process believed to be mediated by syptojanin, and is accompnied by the disassembly of clathrin. |
| Species | Homo sapiens |
| nCoCo Score | 673 |
| Base PAG ID | WAG001028 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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